Despite decades of research, morphogenesis along the various body axes remains one of the major mysteries in developmental biology. A milestone in the field was the realisation that a set of closely related regulators, called Hox genes, specifies the identity of body segments along the anterior–posterior (AP) axis in most animals. Hox genes have been highly conserved throughout metazoan evolution and code for homeodomain‐containing transcription factors. Thus, they exert their function mainly through activation or repression of downstream genes. However, while (...) much is known about Hox gene structure and molecular function, only a few target genes have been identified and studied in detail. Our knowledge of Hox downstream genes is therefore far from complete and consequently Hox‐controlled morphogenesis is still poorly understood. Genome‐wide approaches have facilitated the identification of large numbers of Hox downstream genes both in Drosophila and vertebrates, and represent a crucial step towards a comprehensive understanding of how Hox proteins drive morphological diversification. In this review, we focus on the role of Hox genes in shaping segmental morphologies along the AP axis in Drosophila, discuss some of the conclusions drawn from analyses of large target gene sets and highlight methods that could be used to gain a more thorough understanding of Hox molecular function. In addition, the mechanisms of Hox target gene regulation are considered with special emphasis on recent findings and their implications for Hox protein specificity in the context of the whole organism. BioEssays 30:965–979, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

When, in 1735, Alexander Gottlieb Baumgarten added a new discipline to the philosophical system, he not only founded modern aesthetics but also contributed to shaping the modern concept of art or 'fine art'. In The Founding of Aesthetics in the German Enlightenment, Stefanie Buchenau offers a rich analysis and reconstruction of the origins of this new discipline in its wider context of German Enlightenment philosophy. Present-day scholars commonly regard Baumgarten's views as an imperfect prefiguration of Kantian and post-Kantian aesthetics, (...) but Buchenau argues that Baumgarten defended a consistent and original project which must be viewed in the context of the modern debate on the art of invention. Her book offers new perspectives on Kantian aesthetics and beauty in art and science. (shrink)

In this study, Limburgian and Dutch 2.5- to 4-year-olds and adults took part in a word learning experiment. Following the procedure employed by Quam and Swingley (2010) and Singh et al. (2014), participants learned two novel word-object mappings. After training, word recognition was tested in correct pronunciation (CP) trials and mispronunciation (MP) trials featuring a pitch change. Since Limburgian is considered a restricted tone language, we expected that the pitch change would hinder word recognition in Limburgian, but not in non-tonal (...) Dutch listeners. Contrary to our expectations, both Limburgian and Dutch children appeared to be sensitive to pitch changes in newly learned words, indicated by a significant decrease in target fixation in MP trials compared to CP trials. Limburgian and Dutch adults showed very strong naming effects in both trial types. The results are discussed against the background of the influence of the native prosodic system. (shrink)

Response to Don Baxter, Don Garrett and Jennifer Marusic regarding my book Imagined Causes: Hume's Conception of Objects; initially delivered at the 2016 Hume Conference in Sydney, Australia as part of the Author Meets Critics session.

Name der Zeitschrift: Naharaim Jahrgang: 9 Heft: 1-2 Seiten: 4-24.

Based on a qualitative study of 48 teenage mothers living in the Denver metropolitan area, this research examines the loss of multiple attachments, including mothers, siblings, and other extended family members and friends, among African American and Latina girls who become young mothers. Through life history narratives, this article explores the isolating effects of teen motherhood on the relational world of young mothers and the transition to “forced autonomy” that emerges out of the relationship strains in the teen mothers’ lives. (...) Faced with ruptures in significant childhood attachments and strains in the mother–daughter bond, young mothers develop strategies of accommodation to cope with the disruptions to connectivity and the demands of forced autonomy that are the result of early motherhood. These findings are interpreted through the frame of self-in-relation theory as this theoretical perspective has been informed by the scholarship on race and ethnicity. In reengaging the discourse on race, class, and gender, our findings contribute to the field in a number of significant and related ways: first, through an investigation into relationship loss and repair among teen mothers; second, by addressing the conditions under which teen mothers gain acceptance in their families; and third, in applying self-in-relation theory to the experience of adolescent girls of color whose relational lives are disrupted by the stigma and adversity of teen motherhood. (shrink)

My paper is concerned with the relation between ought-statements and intentions in Wilfrid Sellars’s philosophy. According to an entrenched view in Sellars scholarship, Sellars considers ought-statements as expressions of we-intentions. The aim of my paper is to question this reading and to propose an alternative. According to this alternative reading of Sellars, ought-statements are metalinguistic statements about the implication relations between intentions. I show that the entrenched understanding faces many unacknowledged problems and generates incompatibilities with Sellars’s commitments about intentions. I (...) argue that the alternative account can help to resolve these problems. A second reason in support of the alternative understanding of Sellars is provided by historical considerations. I argue that my alternative account can be discerned in Sellars’s most developed views about intentions and ought-statements. I also discuss problems and questions which the alternative reading itself faces. (shrink)

For three centuries, concepts of the state have been animated by one of the most powerful metaphors in politics: the body politic, a claustrophobic and bounded image of sovereignty. Climate change, neoliberalism, mass migration, and other aspects of the late Anthropocene have increasingly revealed the limitations of this metaphor. Just as the human body is not whole and separate from other bodies--comprising microbes, bacteria, water, and radioactive isotopes--Stefanie R. Fishel argues that the body politic of the state exists in (...) dense entanglement with other communities and forms of life. Drawing on insights from continental philosophy, science and technology studies, and international relations theory, this path-breaking book critiques the concept of the body politic on the grounds of its very materiality. Fishel both redefines and extends the metaphor of the body politic and its role in understanding an increasingly posthuman, globalized world politics. By conceiving of bodies and states as lively vessels, living harmoniously with multiplicity and the biosphere, she argues that a radical shift in metaphors can challenge a politics based on fear to open new forms of global political practice and community. Reframing the concept of the body politic to accommodate greater levels of complexity, Fishel suggests, will result in new configurations for the political and social organization necessary to build a world in which the planet's inhabitants do not merely live but actively thrive. (shrink)

At the centre of this study is the theoretical and empirical analysis of action-formation mechanisms in norm-relevant, situations. Basically two mechanisms are employed, namely action according to a) moral principles and b) the principle of deterrence. Conflicting assumptions concerning the way these mechanisms work are deduced from two theoretical perspectives, the high-cost/low-cost. hypothesis and Situational Action Theory (SAT). While the high-cost/low-cost. hypothesis leads to the assumption that, criminal action is explained by the principle of deterrence in high-cost, situations and, in (...) low-cost, situations, by moral principles, it. follows from SAT that., in high-cost, situations, the principle of deterrence has an effect, only on those persons with weak moral principles, and influences of moral principles are expected in low-cost, situations. Empirical analysis of these hypotheses is conducted with the help of data that, have been collected as part, of a mail survey (n=2383) of a disproportionately layered random sample of residents of an East. German city. Data analyses are carried out. in order to estimate the influences of the theoretically specified predictors simultaneously for high-cost, and low-cost, situations with multiple group comparisons. The study’s results partially support, both theoretical perspectives. They are finally discussed with respect, to theoretical and methodological aspects. (shrink)

Resumo: A proposta desse trabalho é repensar a linguagem, tema central da filosofia contemporânea, não mais como um instrumento do qual o sujeito se apropria e desapropria de acordo com a própria vontade, mas, juntamente com Heidegger, como a própria casa do ser. A função de comunicação é apenas uma das múltiplas possibilidades da linguagem. Com Heidegger é desenvolvida a questão de como a fenomenologia transforma-se em hermenêutica e de como a autocompreensão surge paralela a toda compreensão. A filosofia autêntica (...) é aquela na qual, ao questionar-se sobre algo, o sujeito é inserido na própria questão. A compreensão nunca é impessoal, pois a aletheia perpassa o sujeito que, ao compreender algo, está compreendendo a si mesmo. Palavras-chave: Filosofia. Martin Heidegger. Linguagem. Lógica. Verdade. Metafísica.: The purpose of this paper is to rethink the language, the central theme of contemporary philosophy, not as an instrument to which the subject is appropriate and unappropriate according to their will, but, along with Heidegger, as the house of being. The function of communication is only one of the many possibilities of language. With Heidegger is developed the question of how phenomenology turns to hermeneutics and how the selfunderstanding is parallel to all understanding. The authentic philosophy is that in which is questioned about something and the subject is inserted in the issue. The understanding is never impersonal, therefore Aletheia permeates the subject that by understanding something is to understand yourself. Keywords: Philosophy. Martin Heidegger. Language. Logic. Thuth. Metaphysics. (shrink)

How is violence conventionally portrayed and where does violence lie in representation? How does photography mediate the relationships between different forms and ideas, moments and experiences of violence? These were some of the questions addressed in a conversation between artist Harri Pälviranta and philosopher Stefanie Baumann organized by Alexandra Athanasiadou, founder and director of the online platform Philosophy & Photography Lab (PHLSPH), during the international Photography Festival, Imago Lisboa, in Lisbon during October 2022. The discussion presented here is edited (...) from a transcript by Athanasiadou. It took place at Lusófona University in Lisbon on the occasion of Pälviranta’s exhibition at the Museu Nacional de Arte Contemporânea (MNAC) (6 October 2021–8 January 2023) and focuses on two series of works in the exhibition, News Portraits and Choreography of Violence. (shrink)

Stefanie Buchenau | : Johann Georg Sulzer participe d’une tradition allemande et wolffienne qui conjugue réflexion épistémologique et esthétique. L’originalité de Sulzer au sein de cette tradition consiste à développer un nouveau modèle de la connaissance comme contemplation. Selon ce modèle spéculatif qui emprunte des éléments à l’esthétique de Du Bos, la distance et l’extériorité du spectateur par rapport à son objet est loin d’être le réquisit d’une bonne vision. Celle-ci dépend tout au contraire de l’appartenance du spectateur au (...) monde qu’il contemple, de sa réceptivité, de sa sensibilité et de son humanité. Car l’âme ne peut déployer son activité de pensée qu’à condition de s’attacher d’abord à son objet : un tel attachement est la condition de son détachement. La mise en place de ce nouveau modèle spéculatif répond à l’injonction de Mérian qui est de repenser la conscience ou l’aperception à partir d’un sentiment a posteriori. Car « l’oeil ne se voit pas voir », et l’aperception primitive, cet acte par lequel l’esprit se pense, lui échappe. Il éprouve néanmoins des sentiments — de plaisir et de déplaisir — qui le contraignent à faire retour sur lui-même et sur son état d’être affecté ; des sentiments dont Sulzer considère qu’ils ancrent sa connaissance dans la réalité et lui permettent de la rapporter à soi-même. C’est ainsi qu’au fil des mémoires académiques des années 1750 à 1770, Sulzer élabore une nouvelle conception tripartite des facultés, et une distinction entre domaines théorique et pratique qui marquera la philosophie de Kant. Ce débat au sein de l’Académie berlinoise au sujet de la connaissance de soi donne une nouvelle orientation anthropologique à la philosophie allemande de la seconde moitié du xviiie siècle. | : Johann Georg Sulzer belongs to a German and Wolffian tradition that closely associates theory of knowledge and aesthetics. Sulzer’s originality within this tradition consists in introducing a new model of contemplation. This model borrows elements from Du Bos and leads him to revise the traditional paradigms of cognition and self-cognition : more than the spectator’s distance and exteriority to her object, good vision requires her involvement and inclusion into the world she contemplates, that is her receptivity, sensibility and humanity. For her soul cannot unfold its activity unless it is attached to its object. Such attachment is the condition of its detachment. Sulzer elaborates his model of speculation in response to issues recently raised by his colleague Merian within the Berlin academy. Merian had emphasized the necessity to rethink consciousness or apperception on the basis of some posteriori feeling. For “the eye does not see itself seeing” and the primitive apperception, the act of thinking itself, necessarily escapes the soul’s aperception : it nonetheless has feelings — of pleasure and displeasure — which make the soul reflect on itself and its state of affection ; For Sulzer, these feelings are what grounds knowledge in reality and establishes a relation to the self. In his writings from the 1750’ies to the 1770’ies Sulzer develops these insights and elaborates a new division of faculties and of the theoretical vs. practical that will shape Kant’s psychology and philosophy. This debate within the Berlin academy confers a new anthropological orientation to the German philosophy of the second 18th century. (shrink)

This paper shows that Hume was ultimately forced to conclude in The Treatise that all demonstrative and intuited claims can in fact, be imagined as otherwise. As a result, he was forced to conclude that all knowledge claims must, ultimately, reduce to probable claims, or in Hume’s own, and indisputably clear words: “all knowledge degenerates into probability." As a further result, it is suggested (briefly) that this anticipates Quine’s well-known attack on the analytic / synthetic distinction (Quine 1953).

Recuperating the sibling -- Sibling logic -- Fraternity and revolution -- The shadows of fraternity -- Economizing desire : the sibling (in) law -- Genealogical sciences -- Living languages : comparative philology and evolution -- The east comes home : race and religion.

Der Band widmet sich den Spezifika des Verhältnisses zwischen Religion, Ethik und Politik in der modernen Gesellschaft. Die versammelten Beiträge klären insbesondere, welche inhaltlichen Verbindungen und institutionellen Trennlinien der (säkulare) demokratische Rechtsstaat erlaubt bzw. auch verlangt. Ob die Politik dabei ihre eigene "Moral" ausbilden muss, weil die ethische und religiöse Kardinalfrage nach dem "guten" Leben ihren Bereich überfordert, wird anhand von zahlreichen aktuellen religionspolitischen Problemkreisen erörtert."-- Back cover.

Although Symons' recent book, On Dennett (Wadsworth, 2002), provides scientists with ahelpful, general introduction to Dennett'sthought, it presents a skewed version of the history of the philosophy of mind. In particular, the continental tradition is almost entirely ignored, if not glibly dismissed. As aresult, the unwary reader of this book wouldnever realize that Dilthey, Sartre and Husserl,like Dennett, offer a ``middle ground'' between naturalistic realism and naturalistic eliminativism. However, unlike Dennett, the respective positions of Dilthey, Sartre and Husserl are not (...) ontologically indifferent, but instead, present a non-naturalistic form of realism that does not simultaneously invoke Cartesian dualism. (shrink)

Centered on the collection of pre-conquest antiquities formed by Miguel Garcés, a Puno landowner and antiquary, this article studies the creole antiquarian landscape of the Southern Andes over the late 1800s and early 1900s. Historians have commonly taken the fact that many of the area's private collections were later sold to museums abroad as a testament to this antiquarian landscape's fragility and precariousness. This article argues that the collections' very volatility, dissolution, and mobility also, somewhat paradoxically, contributed to their centrality. (...) Indeed, many of these collections from “provincial” Peruvian and Bolivian localities would leave a decisive mark on the period's most visible museums of Americana in metropolitan centers—by their sheer scale and number, but also through their composition, prestige, and aesthetic appeal. The article thus contributes to an ongoing rethinking of the histories of anthropology and archaeology more broadly—by making visible Hispanic American contributions and the ways in which they were subsumed by, and constitutive of, the very “core” of these fields. The Southern Andes, the article holds, ought to be seen in many ways as a center, not a periphery, of Americanist learning, collecting, and display. (shrink)

The principle of sustainability contains two objectives of justice regarding the conservation and use of ecosystems and their services : global justice between different people of the present generation ; justice between people of different generations. Three hypotheses about their relationship — independency, facilitation and rivalry — are held in the political and scientific sustainability discourse. Applying the method of qualitative content analysis to important political documents and the scientific literature, we reveal six determinants underlying the different hypotheses: quantity and (...) quality of ecosystem services, population development, substitutability of ecosystem services, technological progress, institutions and political restrictions. (shrink)

This article shows that in 1.4.2.15-24 of the Treatise of Human Nature, Hume presents his own position on objects, which is to be distinguished from both the vulgar and philosophical conception of objects. Here, Hume argues that objects that are effectively imagined to have a “perfect identity” are imagined due to the constancy and coherence of our perceptions (what we may call ‘level 1 constancy and coherence’). In particular, we imagine that objects cause such perceptions, via what I call ‘indirect (...) causation.’ In virtue of imagining ideas of objects that have a perfect identity, our perceptions seem to be even more constant and coherent (what we may call ‘level 2 constancy and coherence’). Thus, in addition to seeing that Hume is presenting his own position on objects in this section of the Treatise, we see that he is working with a previously unrecognized kind of causation, i.e., indirect causation, and that he has two kinds of constancy and coherence in mind: level 1 and level 2. (shrink)

The distinction between the manifest and the scientific image of man- in-the-world is widely seen as crucial to Wilfrid Sellars's philosophical work. The present essay agrees with this view. It contends, however, that precisely because the distinction is important, we should not hurry to a quick and superficial understanding of it. The essay identifies several oversimplifications that can be found in the literature on the topic and argues that they are at least partly rooted in too rigid a view of (...) the role that the two-image distinction plays in Sellars's philosophy. It shows that this rigid approach is quite common in the secondary literature, either explicitly or by implication. It then presents a more cautious, flexible approach to the problem of the two images and explains why this approach is fruitful on the basis of textual evidence, along with the overall advantages of interpreting Sellars's thought as a whole. (shrink)

BackgroundEverybody has the right to decide whether to receive specific medical treatment or not and to provide their free, prior and informed consent to do so. As dementia progresses, people with Alzheimer’s dementia (PwAD) can lose their capacity to provide informed consent to complex medical treatment. When the capacity to consent is lost, the autonomy of the affected person can only be guaranteed when an interpretable and valid advance directive exists. Advance directives are not yet common in Germany, and their (...) validity is often questionable. Once the dementia diagnosis has been made, it is assumed to be too late to write an advance directive. One approach used to support the completion of advance directives is ‘Respecting Choices’®—an internationally recognised, evidence-based model of Advance Care Planning (ACP), which, until now, has not been evaluated for the target group of PwAD. This study’s aims include (a) to investigate the proportion of valid advance directives in a memory clinic population of persons with suspected AD, (b) to determine the predictors of valid advance directives, and (c) to examine whether the offer of ACP can increase the proportion of valid advance directives in PwAD.MethodWe intend to recruit at leastN = 250 participants from two memory clinics in 50 consecutive weeks. Of these, the first 25 weeks constitute the baseline phase (no offer of ACP), the following 25 weeks constitute the intervention phase (offer of ACP). The existence and validity of an advance directive will be assessed twice (before and after the memory clinic appointment). Moreover, potential predictors of valid advance directives are assessed.DiscussionThe results of this study will enhance the development of consent procedures for advance directives of PwAD based on the ACP/Respecting Choices (R) approach. Therefore, this project contributes towards increasing the autonomy and inclusion of PwAD and the widespread acceptance of valid advance directives in PwAD.Trial RegistrationDRKS, DRKS00026691, registered 15th of October 2021,https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00026691. (shrink)

In the study of categories whose morphisms display a behaviour similar to that of partial functions, the concept of morphism domain is, obviously, central. In this paper an operation defined on morphisms describes those properties which are related to morphisms being regarded as abstractions of partial functions. This operation allows us to characterise the morphism domains directly, and gives rise to an algebra defined by a simple set of identities. No product-like categorical structures are needed therefore. We also develop the (...) construction of topologies together with the notion of continuous morphism, in order to test the effectiveness of this approach. It is interesting to see how much of the computational character of the morphisms is translated into continuity. (shrink)

Explainable artificial intelligence (XAI) is an emerging, multidisciplinary field of research that seeks to develop methods and tools for making AI systems more explainable or interpretable. XAI researchers increasingly recognise explainability as a context-, audience- and purpose-sensitive phenomenon, rather than a single well-defined property that can be directly measured and optimised. However, since there is currently no overarching definition of explainability, this poses a risk of miscommunication between the many different researchers within this multidisciplinary space. This is the problem we (...) seek to address in this paper. We outline a framework, called Explanatory Pragmatism, which we argue has two attractive features. First, it allows us to conceptualise explainability in explicitly context-, audience- and purpose-relative terms, while retaining a unified underlying definition of explainability. Second, it makes visible any normative disagreements that may underpin conflicting claims about explainability regarding the purposes for which explanations are sought. Third, it allows us to distinguish several dimensions of AI explainability. We illustrate this framework by applying it to a case study involving a machine learning model for predicting whether patients suffering disorders of consciousness were likely to recover consciousness. (shrink)

In this paper we explore quarantining as a more ethical method for delimiting the spread of Hate Speech via online social media platforms. Currently, companies like Facebook, Twitter, and Google generally respondreactivelyto such material: offensive messages that have already been posted are reviewed by human moderators if complaints from users are received. The offensive posts are onlysubsequentlyremoved if the complaints are upheld; therefore, they still cause the recipients psychological harm. In addition, this approach has frequently been criticised for delimiting freedom (...) of expression, since it requires the service providers to elaborate and implement censorship regimes. In the last few years, an emerging generation of automatic Hate Speech detection systems has started to offer new strategies for dealing with this particular kind of offensive online material. Anticipating the future efficacy of such systems, the present article advocates an approach to online Hate Speech detection that is analogous to the quarantining of malicious computer software. If a given post is automatically classified as being harmful in a reliable manner, then it can be temporarily quarantined, and the direct recipients can receive an alert, which protects them from the harmful content in the first instance. The quarantining framework is an example of more ethical online safety technology that can be extended to the handling of Hate Speech. Crucially, it provides flexible options for obtaining a more justifiable balance between freedom of expression and appropriate censorship. (shrink)

The focus of this paper is institutional change and the changing role of business in Germany. Back in the 1980s, the German institutional framework was characterized by implicit mandatory and obligatory regulations that set a clear context for responsible corporate behavior. Today, this framework has eroded and given way to a situation in which corporations explicitly and voluntarily take responsibility for social issues. This shift from implicit to explicit corporate social responsibility is an indication of a major institutional change epitomized (...) by the deconstruction of ‘old’ and the reconstruction of ‘new’ institutions. In the course of this change, corporations, state actors, and civil society organizations compete for their ideas and interests in what we call a fight for myths. The paper traces this fight for myths and the changing understanding of corporate responsibility in Germany. (shrink)

This paper argues that Husserl’s method is partially motivated by an attempt to avoid certain absurdities inherent in Hume’s epistemology. In this limited respect, we may say that Hume opened the door to phenomenology, but as a sacrificial lamb. However, Hume was well aware of his self-defeating position, and perhaps, in some respects, the need for an alternative. Moreover, Hume’s “mistakes” may have incited Husserl’s discovery of the epoche, and thus, transcendental phenomenology.

in kant’s account of cognition, Eric Watkins and Marcus Willaschek distinguish between a ‘broad’ and ‘narrow’ sense of Kant’s use of the term ‘cognition.’ Every “conscious representation that represents an object” counts as a cognition, taken in the broad sense.1 Every “conscious representation of a given object and of its general features” counts as a cognition in the narrow sense.2 In the case of finite beings, they argue, cognition in the narrow sense must fulfill two conditions: First, the object must (...) be given, since cognition must actually latch onto an object, and intuition satisfies that condition insofar as it immediately relates to the object represented in the intuition.... (shrink)

This book provides the first comprehensive account of Hume’s conception of objects in Book I of the Treatise. What, according to Hume, are objects? Ideas? Impressions? Mind-independent objects? All three? None of the above? Through a close textual analysis, I show that Hume thought that objects are imagined ideas. However, I argue that he struggled with two accounts of how and when we imagine such ideas. On the one hand, Hume believed that we always and universally imagine that objects are (...) the causes of our perceptions. On the other hand, he thought that we only imagine such causes when we reach a “philosophical” level of thought. This tension manifests itself in Hume’s account of personal identity; a tension that, I argue, Hume acknowledges in the Appendix to the Treatise. As a result of presenting a detailed account of Hume’s conception of objects, we are forced to accommodate new interpretations of, at least, Hume’s notions of belief, personal identity, justification and causality. (shrink)